Autism heritability: It probably does not mean what you think it means

The question of autism’s heritability is compelling for researchers and laypeople alike, but many people in both groups misunderstand its definition.

Heritability is defined as the proportion of variation in a condition that is attributable to variation in genetics. Heritability estimates can influence how much time and money researchers like me think should be allocated to studying genetic factors versus environmental ones. For families with a history of autism, heritability estimates get right to the heart of the nature-versus-nurture debate, by offering clues about which factors led to an individual’s diagnosis.

These numbers have substantial implications; they probably should not. Autism arises from a complex interplay of genetic and environmental factors, and most heritability studies oversimplify these relationships.

Several studies on autism heritability published in the past few years have drawn considerable attention. Those published from 2011 to 2014 estimated heritability to be in the 35 to 50 percent range, but studies published since 2017 have put the number at 64 to 85 percent.

What do these estimates actually mean?

Heritability is often misinterpreted as the proportion of a condition that is caused by genes. However, that interpretation is not quite correct. Or rather, so many asterisks must be attached in order for it to be correct, that it could not be, by any stretch of the imagination, considered to be correct.

Heritability estimates may tell us to what extent a person’s genetics predispose them to a condition. But they tell us nothing about how different environments cause those genetics to play out.

Representing reality:

First, let me explain why most estimates of heritability are incorrect. Studies that estimate autism’s heritability use a statistical model to try to attribute the condition to either genetics or environment. Mounting evidence suggests this model is too simplistic to explain how autism arises.

The model generally looks something like this: Observed characteristics, or phenotype (P) = genotype (G) + environment (E). The G and E components can each be broken down further to get at specific types of genetic or environmental contributions, but the core point of the model is to separate G and E.

A statistical model is merely a caricature of the real world, though; the extent to which it is useful depends on how well the model reflects reality. The P = G + E model assumes that genetic and environmental influences are independent of each other and that genes do not interact with the environment or with other genes to influence phenotype.

We know in fact that networks of genes interact to influence a person’s odds of having autism and that genetic factors raise the odds of having autism caused by environmental exposures such as infection, air pollution or nutrition.

In short, if reality is more complex than the model, that model may produce inaccurate heritability estimates. There are many more technical reasons why published heritability estimates are likely to be inaccurate1.

Thought experiments:

There is also a much simpler reason why heritability estimates should not be taken at face value: High heritability does not equal genetic causation, and it does not exclude the possibility of environmental influence.

Here are two thought experiments that demonstrate why.

Borrowing an example from the great evolutionary biologist Richard Lewontin, imagine planting a set of identical seeds in a uniform environment that ensures all the seeds receive equal amounts of light and nutrients. Any variation in the heights of the plants that grow from those seeds is solely attributable to genetic variation among the plants. The heritability in this scenario is 100 percent.

Now imagine taking another set of the same seeds and planting them in uniformly suboptimal growing conditions, with limited light and nutrients. The plants’ growth would be stunted, and again the heritability would be 100 percent.

The point is: Even where heritability is estimated to be 100 percent, the environment can influence phenotype. Of course, this is not limited to plants. For example, the heritability of human height is estimated to be approximately 80 percent, but height is still strongly regulated by a person’s nutritional environment.

Next, consider this example from David S. Moore and David Shenk2. Imagine a bucket of water into which person A pours 40 liters of water and person B pours 60 liters of water. Clearly, 40 percent of the water is ‘attributable’ to person A, 60 percent to person B. Now imagine the same bucket, but this time person A turns on the faucet and person B holds the hose. How much of the water in the bucket is due to person A and how much is due to person B?

In short, when causes interact to create an outcome, it becomes nonsensical to try to apportion credit (or blame) to one cause independent of the other.

The bucket example is not just a thought experiment; it represents conditions that have both genetic and environmental components.

Consider the condition phenylketonuria, which occurs in people who have genetic variants that affect how their bodies metabolize the amino acid phenylalanine. The condition does not occur in the absence of the genetic variants, but it also does not occur if phenylalanine is removed from the diet. So how much of it can be attributed to genes versus the environment?

Complex causes:

The consequences of miscasting heritability as the contribution of genetics to any given individual’s diagnosis are potentially dire. As well as misinforming the public, it could throw funding for research on the etiology of autism entirely into genetic research rather than into how genes and environment interact.

This should cause genetic and environmental researchers alike great concern.

The search for rare genetic variants that may cause autism has yielded many important findings, but the search for common variants, whose influence combines to raise autism’s odds, has been less fruitful. There are likely to be many of these variants, each exerting only weak effects, which makes them undetectable except in massive study samples. It is also highly likely that many common variants do not exert an effect unless they are present along with another genetic or environmental factor.

Animal models that explore genetic factors in the absence of relevant environmental interactions could be doomed never to recapitulate those genetic factors’ effects in people.

In short, many heritability estimates of autism in the literature are likely to be inaccurate and, more importantly, prone to misinterpretation. Rather than asking: “Are genes or the environment responsible for autism?” we should be asking: “How are genes and the environment responsible for autism?”

Brian Lee is associate professor of epidemiology and biostatistics at Drexel University in Philadelphia, Pennsylvania.

References:
  1. Tenesa A. and C.S. Haley Nat. Rev. Genet. 14, 139-149 (2013) PubMed
  2. Moore D.S. and D. Shenk Wiley Interdiscip. Rev. Cogn. Sci. 8, e1400 (2017) PubMed

Originally published on Spectrum

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